登录：
完成课程的时间：43分钟。
需要帮忙？访问我们的帮助中心。
Try our lab safety simulation
Discover one of 200+ learning simulations available today
About Gene RegulationVirtual Lab Simulation
Welcome to the future of medicine! In this simulation, you will learn the gene regulation principle that won the Nobel Prize for Physiology 2012. With the gene regulation technique develop by Sir Gurdon and Shinya Yamanaka, your mission is to try to treat Amy, who is visually impaired, to try to help her regain her sight.
学习干细胞的基础知识
为了帮助治疗Amy，您将从女孩中取出的成纤维细胞样品中制备诱导的多能干细胞（IP）。然后，IPS细胞将分化为视网膜色素上皮细胞进行移植。在此模拟中，3D动画将使您仔细研究基因调节所涉及的机械。您将了解干细胞的基础知识以及创建一个干细胞的基础知识。
Transform fibroblast cells into iPS cells
您将必须根据您在以前的任务中学到的知识来确定哪些转录因子在维持干细胞的功能方面至关重要。确定基因后，您将使用逆转录病毒感染技术将成熟的成纤维细胞转化为IPS细胞。孵育后，您将检查哪些转录因子能够诱导成纤维细胞进入干细胞（IPS）。
Analyze gene expression
By now you will have an idea of which transcription factor is capable of transforming fibroblast cells into iPS cells. The next step is to confirm your findings by analyzing the gene expression in mRNA and protein level. You will perform reverse transcription PCR (RT-PCR) and Western blot to investigate the mRNA and protein level, respectively. Finally, you will have to decide which set of transcription factors can be used to transform fibroblast cells into iPS effectively. Will you able to help the doctor in treating Amy?
Get Started Now
Open your eyes to the vast potential of gene regulation, where you can reprogram cells into any cell that fits your needs. Will you able to help the doctor in restoring the sight of a visually impaired girl?
技术in Lab
- 显微镜
- RT-PCR
- Western印迹
学习目标
在此模拟结束时，您将能够…
- Explain how gene expression can be regulated
- 描述不同水平的基因调节（mRNA和蛋白质）
- Measure mRNA levels (RT-PCR), protein expression (Western blotting)
仿真功能
Length- 43分钟
语言– English, Spanish
Examples of Related Standards
University
Life Science related 1st year onwards
基因调节的屏幕截图Virtual Lab Simulation
这个怎么运作
您的浏览器中的一百万美元实验室
Perform experiments in virtual lab simulations to achieve core science learning outcomes.
我们所有的模拟运华体会赞助ac米兰行在笔记本电脑和桌面排版uters, and you can play our simulations without having to install any browser plugins.
数百小时的科学学习内容
我们的虚拟实验室模拟ulations are aimed at university, college and high school level, within fields such as biology, biochemistry, genetics, biotechnology, chemistry, physics and more.
通过访问我们的模拟，您将拥有数百小时的华体会赞助ac米兰吸引人，高质量的学习内容。
Discover more Virtual Lab Simulations
We currently have233 simulationsthat cover everything from biology and medicine to physics and chemistry.
