细菌中的遗传转移：防止超级细菌的兴起！

由于强大的抗生素在治疗多耐药细菌方面，人类处于严重的危险中，也称为超级细菌。在此模拟中，您将了解这些超级细菌的强大能力。您的任务是找出他们如何获得外国DNA，使他们成为超级细菌。

Beat Dr. One in the board game ”Superbugs!”

In this simulation, you will try to beat Dr. One in a board game. This board game isn’t like other board games, however. Here, you will learn about the spread of bacterial infection and try to prevent a global pandemic! Dr. One is the enemy, trying to wipe out the human race, and it’s your task to save them! While playing this game, you will learn the key concepts of horizontal gene transfer in bacteria.

学习细菌遗传学的基础知识

First, you will learn about mutation and genetic elements of bacteria, which include chromosomes and plasmids. You will recreate the famous Microbial Evolution and Growth Arena (MEGA) plate developed by Harvard University and Technion-Israel Institute of Technology to highlight the inheritance of antibiotic resistance across many generations of bacteria. You have the freedom to decide where to grow your culture and how to set the antibiotic concentration levels. In the process, you will strengthen your understanding of the concept of mutation and its relation to the development of antibiotic resistance in bacteria.

Perform bacteria culture experiments

抗生素耐药性的传播不仅是遗传随机基因突变的结果。通过用鲍马尼杆菌的抗性菌株分析患者的样品，您将能够鉴定出细菌可以用来获取外源DNA的三种水平基因转移方法。您将使用样本和控件设置琼脂板，并完成一系列小型学习游戏，以了解结合，转换和转导背后的机制和概念。

Dive into the microbe realm

完成实验和学习活动后，您将实际上迈向微观世界。根据您对细菌的特征和周围环境的观察，随着细菌，质粒和噬菌体的漂浮，您的任务是找出哪种水平基因转移。

Will you be able to grasp all the learning concepts behind the acquisition of antibiotic resistance? And will you be able to prevent Dr. One from winning the board game and wiping out the human race? We hope so!